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Use of a failure probability constraint to suggest an initial dose in a phase I cancer clinical trial
The primary objective of a Phase I cancer clinical trial is to determine the maximum tolerated dose of a drug. The “failure probability” was proposed and used as a constraint to help identify a suitable initial dose range. The maximum tolerated dose was then determined based on a 3 + 3 cohort-based...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taiwan Food and Drug Administration
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355001/ https://www.ncbi.nlm.nih.gov/pubmed/28911474 http://dx.doi.org/10.1016/j.jfda.2013.12.004 |