G9a dictates neuronal vulnerability to inflammatory stress via transcriptional control of ferroptosis

Neuroinflammation leads to neuronal stress responses that contribute to neuronal dysfunction and loss. However, treatments that stabilize neurons and prevent their destruction are still lacking. Here, we identify the histone methyltransferase G9a as a druggable epigenetic regulator of neuronal vulne...

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Detalles Bibliográficos
Autores principales: Rothammer, Nicola, Woo, Marcel S., Bauer, Simone, Binkle-Ladisch, Lars, Di Liberto, Giovanni, Egervari, Kristof, Wagner, Ingrid, Haferkamp, Undine, Pless, Ole, Merkler, Doron, Engler, Jan Broder, Friese, Manuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355351/
https://www.ncbi.nlm.nih.gov/pubmed/35930635
http://dx.doi.org/10.1126/sciadv.abm5500

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