Neonatal BCG vaccination is associated with a long-term DNA methylation signature in circulating monocytes

Trained immunity describes the capacity of innate immune cells to develop heterologous memory in response to certain exogenous exposures. This phenomenon mediates, at least in part, the beneficial off-target effects of the BCG vaccine. Using an in vitro model of trained immunity, we show that BCG ex...

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Detalles Bibliográficos
Autores principales: Bannister, Samantha, Kim, Bowon, Domínguez-Andrés, Jorge, Kilic, Gizem, Ansell, Brendan R. E., Neeland, Melanie R., Moorlag, Simone J. C. F. M., Matzaraki, Vasiliki, Vlahos, Amanda, Shepherd, Rebecca, Germano, Susie, Bahlo, Melanie, Messina, Nicole L., Saffery, Richard, Netea, Mihai G., Curtis, Nigel, Novakovic, Boris
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355358/
https://www.ncbi.nlm.nih.gov/pubmed/35930640
http://dx.doi.org/10.1126/sciadv.abn4002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355358/
https://www.ncbi.nlm.nih.gov/pubmed/35930640
http://dx.doi.org/10.1126/sciadv.abn4002

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