Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
The tumor microenvironment (TME) is a microecology consisting of tumor and mesenchymal cells and extracellular matrices. The TME plays important regulatory roles in tumor proliferation, invasion, metastasis, and differentiation. Neuroendocrine differentiation (NED) is a mechanism by which castration...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355504/ https://www.ncbi.nlm.nih.gov/pubmed/35938167 http://dx.doi.org/10.3389/fcell.2022.955669 |
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author | Zhou, Hengfeng He, Qiangrong Li, Chao Alsharafi, Bassam Lutf Mohammed Deng, Liang Long, Zhi Gan, Yu |
author_facet | Zhou, Hengfeng He, Qiangrong Li, Chao Alsharafi, Bassam Lutf Mohammed Deng, Liang Long, Zhi Gan, Yu |
author_sort | Zhou, Hengfeng |
collection | PubMed |
description | The tumor microenvironment (TME) is a microecology consisting of tumor and mesenchymal cells and extracellular matrices. The TME plays important regulatory roles in tumor proliferation, invasion, metastasis, and differentiation. Neuroendocrine differentiation (NED) is a mechanism by which castration resistance develops in advanced prostate cancer (PCa). NED is induced after androgen deprivation therapy and neuroendocrine prostate cancer (NEPC) is established finally. NEPC has poor prognosis and short overall survival and is a major cause of death in patients with PCa. Both the cellular and non-cellular components of the TME regulate and induce NEPC formation through various pathways. Insights into the roles of the TME in NEPC evolution, growth, and progression have increased over the past few years. These novel insights will help refine the NEPC formation model and lay the foundation for the discovery of new NEPC therapies targeting the TME. |
format | Online Article Text |
id | pubmed-9355504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-93555042022-08-06 Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer Zhou, Hengfeng He, Qiangrong Li, Chao Alsharafi, Bassam Lutf Mohammed Deng, Liang Long, Zhi Gan, Yu Front Cell Dev Biol Cell and Developmental Biology The tumor microenvironment (TME) is a microecology consisting of tumor and mesenchymal cells and extracellular matrices. The TME plays important regulatory roles in tumor proliferation, invasion, metastasis, and differentiation. Neuroendocrine differentiation (NED) is a mechanism by which castration resistance develops in advanced prostate cancer (PCa). NED is induced after androgen deprivation therapy and neuroendocrine prostate cancer (NEPC) is established finally. NEPC has poor prognosis and short overall survival and is a major cause of death in patients with PCa. Both the cellular and non-cellular components of the TME regulate and induce NEPC formation through various pathways. Insights into the roles of the TME in NEPC evolution, growth, and progression have increased over the past few years. These novel insights will help refine the NEPC formation model and lay the foundation for the discovery of new NEPC therapies targeting the TME. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9355504/ /pubmed/35938167 http://dx.doi.org/10.3389/fcell.2022.955669 Text en Copyright © 2022 Zhou, He, Li, Alsharafi, Deng, Long and Gan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Zhou, Hengfeng He, Qiangrong Li, Chao Alsharafi, Bassam Lutf Mohammed Deng, Liang Long, Zhi Gan, Yu Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer |
title | Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
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title_full | Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
|
title_fullStr | Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
|
title_full_unstemmed | Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
|
title_short | Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
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title_sort | focus on the tumor microenvironment: a seedbed for neuroendocrine prostate cancer |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355504/ https://www.ncbi.nlm.nih.gov/pubmed/35938167 http://dx.doi.org/10.3389/fcell.2022.955669 |
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