Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer

The tumor microenvironment (TME) is a microecology consisting of tumor and mesenchymal cells and extracellular matrices. The TME plays important regulatory roles in tumor proliferation, invasion, metastasis, and differentiation. Neuroendocrine differentiation (NED) is a mechanism by which castration...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhou, Hengfeng, He, Qiangrong, Li, Chao, Alsharafi, Bassam Lutf Mohammed, Deng, Liang, Long, Zhi, Gan, Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355504/
https://www.ncbi.nlm.nih.gov/pubmed/35938167
http://dx.doi.org/10.3389/fcell.2022.955669
_version_ 1784763309222789120
author Zhou, Hengfeng
He, Qiangrong
Li, Chao
Alsharafi, Bassam Lutf Mohammed
Deng, Liang
Long, Zhi
Gan, Yu
author_facet Zhou, Hengfeng
He, Qiangrong
Li, Chao
Alsharafi, Bassam Lutf Mohammed
Deng, Liang
Long, Zhi
Gan, Yu
author_sort Zhou, Hengfeng
collection PubMed
description The tumor microenvironment (TME) is a microecology consisting of tumor and mesenchymal cells and extracellular matrices. The TME plays important regulatory roles in tumor proliferation, invasion, metastasis, and differentiation. Neuroendocrine differentiation (NED) is a mechanism by which castration resistance develops in advanced prostate cancer (PCa). NED is induced after androgen deprivation therapy and neuroendocrine prostate cancer (NEPC) is established finally. NEPC has poor prognosis and short overall survival and is a major cause of death in patients with PCa. Both the cellular and non-cellular components of the TME regulate and induce NEPC formation through various pathways. Insights into the roles of the TME in NEPC evolution, growth, and progression have increased over the past few years. These novel insights will help refine the NEPC formation model and lay the foundation for the discovery of new NEPC therapies targeting the TME.
format Online
Article
Text
id pubmed-9355504
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-93555042022-08-06 Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer Zhou, Hengfeng He, Qiangrong Li, Chao Alsharafi, Bassam Lutf Mohammed Deng, Liang Long, Zhi Gan, Yu Front Cell Dev Biol Cell and Developmental Biology The tumor microenvironment (TME) is a microecology consisting of tumor and mesenchymal cells and extracellular matrices. The TME plays important regulatory roles in tumor proliferation, invasion, metastasis, and differentiation. Neuroendocrine differentiation (NED) is a mechanism by which castration resistance develops in advanced prostate cancer (PCa). NED is induced after androgen deprivation therapy and neuroendocrine prostate cancer (NEPC) is established finally. NEPC has poor prognosis and short overall survival and is a major cause of death in patients with PCa. Both the cellular and non-cellular components of the TME regulate and induce NEPC formation through various pathways. Insights into the roles of the TME in NEPC evolution, growth, and progression have increased over the past few years. These novel insights will help refine the NEPC formation model and lay the foundation for the discovery of new NEPC therapies targeting the TME. Frontiers Media S.A. 2022-07-22 /pmc/articles/PMC9355504/ /pubmed/35938167 http://dx.doi.org/10.3389/fcell.2022.955669 Text en Copyright © 2022 Zhou, He, Li, Alsharafi, Deng, Long and Gan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Zhou, Hengfeng
He, Qiangrong
Li, Chao
Alsharafi, Bassam Lutf Mohammed
Deng, Liang
Long, Zhi
Gan, Yu
Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
title Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
title_full Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
title_fullStr Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
title_full_unstemmed Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
title_short Focus on the tumor microenvironment: A seedbed for neuroendocrine prostate cancer
title_sort focus on the tumor microenvironment: a seedbed for neuroendocrine prostate cancer
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355504/
https://www.ncbi.nlm.nih.gov/pubmed/35938167
http://dx.doi.org/10.3389/fcell.2022.955669
work_keys_str_mv AT zhouhengfeng focusonthetumormicroenvironmentaseedbedforneuroendocrineprostatecancer
AT heqiangrong focusonthetumormicroenvironmentaseedbedforneuroendocrineprostatecancer
AT lichao focusonthetumormicroenvironmentaseedbedforneuroendocrineprostatecancer
AT alsharafibassamlutfmohammed focusonthetumormicroenvironmentaseedbedforneuroendocrineprostatecancer
AT dengliang focusonthetumormicroenvironmentaseedbedforneuroendocrineprostatecancer
AT longzhi focusonthetumormicroenvironmentaseedbedforneuroendocrineprostatecancer
AT ganyu focusonthetumormicroenvironmentaseedbedforneuroendocrineprostatecancer