Comparative immunogenicity of an mRNA/LNP and a DNA vaccine targeting HIV gag conserved elements in macaques

Immunogenicity of HIV-1 mRNA vaccine regimens was analyzed in a non-human primate animal model. Rhesus macaques immunized with mRNA in lipid nanoparticle (mRNA/LNP) formulation expressing HIV-1 Gag and Gag conserved regions (CE) as immunogens developed robust, durable antibody responses but low adap...

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Detalles Bibliográficos
Autores principales: Valentin, Antonio, Bergamaschi, Cristina, Rosati, Margherita, Angel, Matthew, Burns, Robert, Agarwal, Mahesh, Gergen, Janina, Petsch, Benjamin, Oostvogels, Lidia, Loeliger, Edde, Chew, Kara W., Deeks, Steven G., Mullins, James I., Pavlakis, George N., Felber, Barbara K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355630/
https://www.ncbi.nlm.nih.gov/pubmed/35935984
http://dx.doi.org/10.3389/fimmu.2022.945706

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355630/
https://www.ncbi.nlm.nih.gov/pubmed/35935984
http://dx.doi.org/10.3389/fimmu.2022.945706

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