Cargando…

Relationship Between MR Spectroscopy-Detected Glutamatergic Neurometabolites and Changes in Social Behaviors in a Pilot Open-Label Trial of Memantine for Adults With Autism Spectrum Disorder

BACKGROUND: The neurobiology underlying ASD is largely unknown but altered neural excitability/inhibitory ratios have been reported. Memantine is an N-methyl-D-aspartate (NMDA) glutamatergic antagonist studied for the treatment of core ASD symptoms, with mixed results. We examined whether glutamater...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nair, Neetu, Hegarty, John Patrick, Cirstea, Carmen Mihaela, Gu, Meng, Appling, Carrina Brooke, Beversdorf, David Quentin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Psychiatry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355704/ https://www.ncbi.nlm.nih.gov/pubmed/35935413 http://dx.doi.org/10.3389/fpsyt.2022.898006

Ejemplares similares

Glutamatergic Neurometabolites in Clozapine-Responsive and -Resistant Schizophrenia
por: Goldstein, Meghan Elizabeth, et al.
Publicado: (2015)

Corrigendum to: Glutamatergic Neurometabolites in Clozapine-Responsive and -Resistant Schizophrenia
Publicado: (2023)

Glutamatergic neurometabolite levels in the caudate are associated with the ability of rhythm production
por: Honda, Shiori, et al.
Publicado: (2023)

Glutamatergic Neurometabolites during Early Abstinence from Chronic Methamphetamine Abuse
por: O’Neill, Joseph, et al.
Publicado: (2015)

N-Acetyl and Glutamatergic Neurometabolites in Perisylvian Brain Regions of Methamphetamine Users
por: Tang, Jinsong, et al.
Publicado: (2018)

T212. LEVELS OF GLUTAMATERGIC NEUROMETABOLITES IN PATIENTS WITH SEVERE TREATMENT-RESISTANT SCHIZOPHRENIA: A PROTON MAGNETIC RESONANCE SPECTROSCOPY STUDY
por: Tarumi, Ryosuke, et al.
Publicado: (2020)

Interaction of Serum Copper and Neurometabolites on Executive Dysfunction in Unmedicated Patients With Major Depressive Disorder
por: Liao, Xiaoxiao, et al.
Publicado: (2021)

Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies
por: Moriguchi, Sho, et al.
Publicado: (2018)

Neurometabolite Levels in Alcohol Use Disorder Patients During Baclofen Treatment and Prediction of Relapse to Heavy Drinking
por: Morley, Kirsten C., et al.
Publicado: (2018)

The Relationship Between Resting Cerebral Blood Flow, Neurometabolites, Cardio-Respiratory Fitness and Aging-Related Cognitive Decline
por: Krishnamurthy, Venkatagiri, et al.
Publicado: (2022)

Editorial: MR Spectroscopy in Neuropsychiatry
por: Egerton, Alice, et al.
Publicado: (2018)

Abnormal neurometabolites in fibromyalgia patients: Magnetic resonance spectroscopy study
por: Jung, Ye-Ha, et al.
Publicado: (2021)

The Relationship Among Gastrointestinal Symptoms, Problem Behaviors, and Internalizing Symptoms in Children and Adolescents With Autism Spectrum Disorder
por: Ferguson, Bradley J., et al.
Publicado: (2019)

S16. GLUTAMATERGIC NEUROMETABOLITE LEVELS IN PATIENTS WITH TREATMENT-RESISTANT SCHIZOPHRENIA: A CROSS-SECTIONAL 3T PROTON MRS STUDY
por: Iwata, Yusuke, et al.
Publicado: (2018)

Neuroanatomical changes of ionotropic glutamatergic and GABAergic receptor densities in male mice modeling idiopathic and syndromic autism spectrum disorder
por: Nardi, Leonardo, et al.
Publicado: (2023)

Glutamatergic Dysfunction and Glutamatergic Compounds for Major Psychiatric Disorders: Evidence From Clinical Neuroimaging Studies
por: Li, Cheng-Ta, et al.
Publicado: (2019)

Examining the Association Between Electrodermal Activity and Problem Behavior in Severe Autism Spectrum Disorder: A Feasibility Study
por: Ferguson, Bradley J., et al.
Publicado: (2019)

Remotely supervised at-home delivery of taVNS for autism spectrum disorder: feasibility and initial efficacy
por: Black, Benjamin, et al.
Publicado: (2023)

Lack of Associations Between Dietary Intake and Gastrointestinal Symptoms in Autism Spectrum Disorder
por: Ferguson, Bradley J., et al.
Publicado: (2019)

Add-On MEmaNtine to Dopamine Antagonism to Improve Negative Symptoms at First Psychosis- the AMEND Trial Protocol
por: Sandström, Katharina O., et al.
Publicado: (2022)

Glutamatergic Neurons in the Amygdala Are Involved in Paclitaxel-Induced Pain and Anxiety
por: Liu, Jiaxin, et al.
Publicado: (2022)

Glutamatergic System in Depression and Its Role in Neuromodulatory Techniques Optimization
por: Khoodoruth, Mohamed Adil Shah, et al.
Publicado: (2022)

2D in-vivo L-COSY spectroscopy identifies neurometabolite alterations in treated multiple sclerosis
por: Quadrelli, Scott, et al.
Publicado: (2019)

Saliva RNA Biomarkers of Gastrointestinal Dysfunction in Children With Autism and Neurodevelopmental Disorders: Potential Implications for Precision Medicine
por: Beversdorf, David Q., et al.
Publicado: (2022)

Safety and Efficacy of Memantine in Children with Autism: Randomized, Placebo-Controlled Study and Open-Label Extension
por: Aman, Michael G., et al.
Publicado: (2017)

Editorial: Precision medicine approaches for heterogeneous conditions such as autism spectrum disorders (The need for a biomarker exploration phase in clinical trials - Phase 2m)
por: Beversdorf, David Q., et al.
Publicado: (2023)

microRNAs and Gene–Environment Interactions in Autism: Effects of Prenatal Maternal Stress and the SERT Gene on Maternal microRNA Expression
por: Beversdorf, David Q., et al.
Publicado: (2021)

Regional White Matter Integrity Predicts Treatment Response to Escitalopram and Memantine in Geriatric Depression: A Pilot Study
por: Krause-Sorio, Beatrix, et al.
Publicado: (2020)

Altered behavior, brain structure, and neurometabolites in a rat model of autism-specific maternal autoantibody exposure
por: Bruce, Matthew R., et al.
Publicado: (2023)

Risk-Conferring Glutamatergic Genes and Brain Glutamate Plus Glutamine in Schizophrenia
por: Bustillo, Juan R., et al.
Publicado: (2017)

Treatment effects on neurometabolite levels in schizophrenia: A meta-analysis dataset of proton magnetic resonance spectroscopy
por: Kubota, Manabu, et al.
Publicado: (2020)

MR-Spectroscopy of GABA and Glutamate/Glutamine Concentrations in Auditory Cortex in Clinical High-Risk for Psychosis Individuals
por: Grent-’t-Jong, Tineke, et al.
Publicado: (2022)

Neurometabolite Levels and Relevance to Central Sensitization in Chronic Orofacial Pain Patients: A Magnetic Resonance Spectroscopy Study
por: Terumitsu, Makoto, et al.
Publicado: (2022)

The Effects of Acupuncture on Glutamatergic Neurotransmission in Depression, Anxiety, Schizophrenia, and Alzheimer's Disease: A Review of the Literature
por: Tu, Cheng-Hao, et al.
Publicado: (2019)

Memantine protects thalamocortical hyper‐glutamatergic transmission induced by NMDA receptor antagonism via activation of system xc(−)
por: Okada, Motohiro, et al.
Publicado: (2019)

Glutamate- and GABA-Modulated Connectivity in Auditory Hallucinations—A Combined Resting State fMRI and MR Spectroscopy Study
por: Weber, Sarah, et al.
Publicado: (2021)

Re-emerging concepts of immune dysregulation in autism spectrum disorders
por: Erbescu, Alina, et al.
Publicado: (2022)

Neurometabolite alterations in traumatic brain injury and associations with chronic pain
por: Robayo, Linda E., et al.
Publicado: (2023)

The Importance of Early Psychological Assessment for Differential Diagnosis and Detection of Comorbidity in Children With Autism Spectrum Disorder
por: Manolova, Harieta, et al.
Publicado: (2021)

Efficacy of Memantine Hydrochloride in Neuropathic Pain
por: Nair, Abhijit S, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_l8sh19g5makj9983sbdet155ic