Cyclooxygenase-2 Upregulated by Temozolomide in Glioblastoma Cells Is Shuttled In Extracellular Vesicles Modifying Recipient Cell Phenotype

Temozolomide (TMZ) resistance is frequent in patients with glioblastoma (GBM), a tumor characterized by a marked inflammatory microenvironment. Recently, we reported that cyclooxygenase-2 (COX-2) is upregulated in TMZ-resistant GBM cells treated with high TMZ concentrations. Moreover, COX-2 activity...

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Detalles Bibliográficos
Autores principales: Lombardi, Francesca, Augello, Francesca Rosaria, Artone, Serena, Ayroldi, Emira, Giusti, Ilaria, Dolo, Vincenza, Cifone, Maria Grazia, Cinque, Benedetta, Palumbo, Paola
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355724/
https://www.ncbi.nlm.nih.gov/pubmed/35936755
http://dx.doi.org/10.3389/fonc.2022.933746

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355724/
https://www.ncbi.nlm.nih.gov/pubmed/35936755
http://dx.doi.org/10.3389/fonc.2022.933746

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