Functional screening reveals HORMAD1-driven gene dependencies associated with translesion synthesis and replication stress tolerance

HORMAD1 expression is usually restricted to germline cells, but it becomes mis-expressed in epithelial cells in ~60% of triple-negative breast cancers (TNBCs), where it is associated with elevated genomic instability (1). HORMAD1 expression in TNBC is bimodal with HORMAD1-positive TNBC representing...

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Detalles Bibliográficos
Autores principales: Tarantino, Dalia, Walker, Callum, Weekes, Daniel, Pemberton, Helen, Davidson, Kathryn, Torga, Gonzalo, Frankum, Jessica, Mendes-Pereira, Ana M., Prince, Cynthia, Ferro, Riccardo, Brough, Rachel, Pettitt, Stephen J., Lord, Christopher J., Grigoriadis, Anita, NJ Tutt, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355871/
https://www.ncbi.nlm.nih.gov/pubmed/35768547
http://dx.doi.org/10.1038/s41388-022-02369-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355871/
https://www.ncbi.nlm.nih.gov/pubmed/35768547
http://dx.doi.org/10.1038/s41388-022-02369-9

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