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Imaging biological macromolecules in thick specimens: The role of inelastic scattering in cryoEM

We investigate potential improvements in using electron cryomicroscopy to image thick specimens with high-resolution phase contrast imaging. In particular, using model experiments, electron scattering theory, Monte Carlo and multislice simulations, we determine the potential for improving electron c...

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Detalles Bibliográficos
Autores principales: Dickerson, Joshua L., Lu, Peng-Han, Hristov, Dilyan, Dunin-Borkowski, Rafal E., Russo, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355893/
https://www.ncbi.nlm.nih.gov/pubmed/35367900
http://dx.doi.org/10.1016/j.ultramic.2022.113510