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Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells
MT1-MMP plays a crucial role in promoting the cellular invasion of cancer cells by degrading the extracellular matrix to create a path for migration. During this process, its localization at the leading edge of migrating cells is critical, and it is achieved by targeted transport of MT1-MMP-containi...
Autores principales: | Gifford, Valentina, Woskowicz, Anna, Ito, Noriko, Balint, Stefan, Lagerholm, B. Christopher, Dustin, Michael L., Itoh, Yoshifumi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355896/ https://www.ncbi.nlm.nih.gov/pubmed/35122963 http://dx.doi.org/10.1016/j.matbio.2022.01.004 |
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