Cargando…
Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
The accumulation of senescent cells is a key characteristic of aging, leading to the progression of age-related diseases such as osteoarthritis (OA). Previous data from our laboratory has demonstrated that high levels of the transmembrane protein connexin 43 (Cx43) are associated with a senescent ph...
Autores principales: | Varela-Eirín, Marta, Carpintero-Fernández, Paula, Guitián-Caamaño, Amanda, Varela-Vázquez, Adrián, García-Yuste, Alejandro, Sánchez-Temprano, Agustín, Bravo-López, Susana B., Yañez-Cabanas, José, Fonseca, Eduardo, Largo, Raquel, Mobasheri, Ali, Caeiro, José Ramón, Mayán, María D. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355945/ https://www.ncbi.nlm.nih.gov/pubmed/35931686 http://dx.doi.org/10.1038/s41419-022-05089-w |
Ejemplares similares
-
Targeting of chondrocyte plasticity via connexin43 modulation attenuates cellular senescence and fosters a pro-regenerative environment in osteoarthritis
por: Varela-Eirín, Marta, et al.
Publicado: (2018) -
The C-terminal domain of connexin43 modulates cartilage structure via chondrocyte phenotypic changes
por: Gago-Fuentes, Raquel, et al.
Publicado: (2016) -
Senolytic activity of small molecular polyphenols from olive restores chondrocyte redifferentiation and promotes a pro-regenerative environment in osteoarthritis
por: Varela-Eirín, Marta, et al.
Publicado: (2020) -
Connexin43 Hemichannel-Mediated Regulation of Connexin43
por: Li, Kai, et al.
Publicado: (2013) -
Connexin43 enhances the expression of osteoarthritis-associated genes in synovial fibroblasts in culture
por: Gupta, Aditi, et al.
Publicado: (2014)