Disease-associated mutations within the yeast DNAJB6 homolog Sis1 slow conformer-specific substrate processing and can be corrected by the modulation of nucleotide exchange factors

Molecular chaperones, or heat shock proteins (HSPs), protect against the toxic misfolding and aggregation of proteins. As such, mutations or deficiencies within the chaperone network can lead to disease. Dominant mutations within DNAJB6 (Hsp40)—an Hsp70 co-chaperone—lead to a protein aggregation-lin...

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Detalles Bibliográficos
Autores principales: Bhadra, Ankan K., Rau, Michael J., Daw, Jil A., Fitzpatrick, James A. J., Weihl, Conrad C., True, Heather L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355953/
https://www.ncbi.nlm.nih.gov/pubmed/35931773
http://dx.doi.org/10.1038/s41467-022-32318-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9355953/
https://www.ncbi.nlm.nih.gov/pubmed/35931773
http://dx.doi.org/10.1038/s41467-022-32318-9

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