Recursive Editing improves homology-directed repair through retargeting of undesired outcomes

CRISPR-Cas induced homology-directed repair (HDR) enables the installation of a broad range of precise genomic modifications from an exogenous donor template. However, applications of HDR in human cells are often hampered by poor efficiency, stemming from a preference for error-prone end joining pat...

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Detalles Bibliográficos
Autores principales: Möller, Lukas, Aird, Eric J., Schröder, Markus S., Kobel, Lena, Kissling, Lucas, van de Venn, Lilly, Corn, Jacob E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356142/
https://www.ncbi.nlm.nih.gov/pubmed/35931681
http://dx.doi.org/10.1038/s41467-022-31944-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356142/
https://www.ncbi.nlm.nih.gov/pubmed/35931681
http://dx.doi.org/10.1038/s41467-022-31944-7

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