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Hypoxia-hindered methylation of PTGIS in endometrial stromal cells accelerates endometriosis progression by inducing CD16(−) NK-cell differentiation
Prostacyclin (PGI(2)) plays key roles in shaping the immune microenvironment and modulating vasodilation, whereas its contribution to endometriosis (EMs) remains largely unclear. Our study suggested that prostacyclin synthase (PTGIS)-dependent PGI(2) signaling was significantly activated in EMs, whi...
Autores principales: | Peng, Haiyan, Weng, Lichun, Lei, Shating, Hou, Shuhui, Yang, Shaoliang, Li, Mingqing, Zhao, Dong |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356144/ https://www.ncbi.nlm.nih.gov/pubmed/35781537 http://dx.doi.org/10.1038/s12276-022-00793-1 |
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