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Protocol to stimulate and delineate alternative lengthening of telomeres in human U2OS cells
Alternative lengthening of telomeres (ALT) is a telomerase-independent but recombination-dependent pathway that maintains telomeres. Here, we describe a protocol to stimulate the formation of ALT-associated PML bodies (APBs) and ALT activity by tethering PML-IV to telomeres in human U2OS cells. Thro...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356160/ https://www.ncbi.nlm.nih.gov/pubmed/35942347 http://dx.doi.org/10.1016/j.xpro.2022.101594 |