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Facile synthesis of 2-hydroxyacetophenone from racemic styrene oxide catalyzed by engineered enzymes
We describe a system that allows for biocatalyzed in vivo synthesis of α-hydroxy ketones from racemic epoxide starting material by in vivo co-expression of native and engineered epoxide hydrolase and alcohol dehydrogenases. The constructed expression system exploits the host cell metabolism for supp...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Netherlands
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356933/ https://www.ncbi.nlm.nih.gov/pubmed/35731351 http://dx.doi.org/10.1007/s10529-022-03271-w |