Caspase 9b Drives Cellular Transformation, Lung Inflammation, and Lung Tumorigenesis

Caspase 9 undergoes alternative splicing to produce two opposing isoforms: proapoptotic Caspase 9a and pro-survival Caspase 9b (C9b). Previously, our laboratory reported that C9b is expressed in majority of non–small cell lung cancer tumors and directly activates the NF-κB pathway. In this study, th...

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Detalles Bibliográficos
Autores principales: Kim, Minjung, Vu, Ngoc T., Wang, Xue, Bulut, Gamze B., Wang, Min-Hsuan, Uram-Tuculescu, Cora, Pillappa, Raghavendra, Kim, Sungjune, Chalfant, Charles E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Cell Fate Decisions
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356980/
https://www.ncbi.nlm.nih.gov/pubmed/35412615
http://dx.doi.org/10.1158/1541-7786.MCR-21-0905

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356980/
https://www.ncbi.nlm.nih.gov/pubmed/35412615
http://dx.doi.org/10.1158/1541-7786.MCR-21-0905

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