The CRTC-CREB axis functions as a transcriptional sensor to protect against proteotoxic stress in Drosophila

cAMP Responsible Element Binding Protein (CREB) is an evolutionarily conserved transcriptional factor that regulates cell growth, synaptic plasticity and so on. In this study, we unexpectedly found proteasome inhibitors, such as MLN2238, robustly increase CREB activity in adult flies through a large...

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Detalles Bibliográficos
Autores principales: Yin, Youjie, Ma, Peng, Wang, Saifei, Zhang, Yao, Han, Ruolei, Huo, Chunyu, Wu, Meixian, Deng, Hansong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357022/
https://www.ncbi.nlm.nih.gov/pubmed/35933423
http://dx.doi.org/10.1038/s41419-022-05122-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357022/
https://www.ncbi.nlm.nih.gov/pubmed/35933423
http://dx.doi.org/10.1038/s41419-022-05122-y

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