Cargando…

SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy

The type I interferon response plays a pivotal role in promoting antitumor immune activity in response to radiotherapy. The identification of approaches to boost the radiation-induced type I interferon response could help improve the efficacy of radiotherapy. Here we show that the histone methyltran...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pan, Dong, Bao, Xuhui, Hu, Mengjie, Jiao, Meng, Li, Fang, Li, Chuan-Yuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2022
Materias:	Tumor Biology and Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357127/ https://www.ncbi.nlm.nih.gov/pubmed/35648422 http://dx.doi.org/10.1158/0008-5472.CAN-21-3523

Ejemplares similares

Tumorous expression of NAC1 restrains antitumor immunity through the LDHA-mediated immune evasion
por: Ren, Yijie, et al.
Publicado: (2022)

A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
por: Kato, Masaki, et al.
Publicado: (2018)

DNGR-1 limits Flt3L-mediated antitumor immunity by restraining tumor-infiltrating type I conventional dendritic cells
por: Cueto, Francisco J, et al.
Publicado: (2021)

Enhanced expression of endogenous retroviruses and of TRIM28 and SETDB1 in children with food allergy
por: Tovo, Pier‐Angelo, et al.
Publicado: (2022)

Enhanced Expression of Human Endogenous Retroviruses, TRIM28 and SETDB1 in Autism Spectrum Disorder
por: Tovo, Pier-Angelo, et al.
Publicado: (2022)

Children with Chronic Immune Thrombocytopenia Exhibit High Expression of Human Endogenous Retroviruses TRIM28 and SETDB1
por: Tovo, Pier-Angelo, et al.
Publicado: (2023)

Combination of radiotherapy and suppression of Tregs enhances abscopal antitumor effect and inhibits metastasis in rectal cancer
por: Ji, Dengbo, et al.
Publicado: (2020)

Intracellular Acetyl CoA Potentiates the Therapeutic Efficacy of Antitumor CD8(+) T Cells
por: Chowdhury, Snehanshu, et al.
Publicado: (2022)

Nicotinamide combined with gemcitabine is an immunomodulatory therapy that restrains pancreatic cancer in mice
por: Selvanesan, Benson Chellakkan, et al.
Publicado: (2020)

Inhibition of tumor‐associated macrophages by trabectedin improves the antitumor adaptive immunity in response to anti‐PD‐1 therapy
por: Belgiovine, Cristina, et al.
Publicado: (2021)

BRCA1 deficiency in mature CD8(+) T lymphocytes impairs antitumor immunity
por: Wu, Bogang, et al.
Publicado: (2023)

MON-909 Diabetic Ketoacidosis Following Treatment of Endogenous Hyperinsulinism
por: Murari, Keerti, et al.
Publicado: (2020)

Expressions of Type I and III Interferons, Endogenous Retroviruses, TRIM28, and SETDB1 in Children with Respiratory Syncytial Virus Bronchiolitis
por: Tovo, Pier-Angelo, et al.
Publicado: (2023)

Pregnancy Is Associated with Impaired Transcription of Human Endogenous Retroviruses and of TRIM28 and SETDB1, Particularly in Mothers Affected by Multiple Sclerosis
por: Tovo, Pier-Angelo, et al.
Publicado: (2023)

Single-cell sequencing reveals antitumor characteristics of intratumoral immune cells in old mice
por: Zhang, Cangang, et al.
Publicado: (2021)

IL-31 induces antitumor immunity in breast carcinoma
por: Kan, Tal, et al.
Publicado: (2020)

RF19 | PSUN368 Surviving Insulinoma: Severe Insulin Resistance in the Face of Endogenous Hyperinsulinemia
por: Azmath, Misbah, et al.
Publicado: (2022)

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
por: Kalim, Khalid W, et al.
Publicado: (2022)

Modulation of lactate-lysosome axis in dendritic cells by clotrimazole potentiates antitumor immunity
por: Wang, Zining, et al.
Publicado: (2021)

Human Endogenous Retroviruses Are Ancient Acquired Elements Still Shaping Innate Immune Responses
por: Grandi, Nicole, et al.
Publicado: (2018)

Endogenous Retroviruses as Targets for Antitumor Immunity in Renal Cell Cancer and Other Tumors
por: Cherkasova, Elena, et al.
Publicado: (2013)

LRIG2 promotes glioblastoma progression by modulating innate antitumor immunity through macrophage infiltration and polarization
por: Hu, Jinyang, et al.
Publicado: (2022)

Vaccination with early ferroptotic cancer cells induces efficient antitumor immunity
por: Efimova, Iuliia, et al.
Publicado: (2020)

Ex vivo blockade of PI3K gamma or delta signaling enhances the antitumor potency of adoptively transferred CD8(+) T cells
por: Dwyer, Connor J., et al.
Publicado: (2020)

Loss of YTHDF1 in gastric tumors restores sensitivity to antitumor immunity by recruiting mature dendritic cells
por: Bai, Xiaowu, et al.
Publicado: (2022)

Endogenous Retroviruses Transcriptional Modulation After Severe Infection, Trauma and Burn
por: Tabone, Olivier, et al.
Publicado: (2019)

Endogenous Retroviruses Provide Protection Against Vaginal HSV-2 Disease
por: Jayewickreme, Radeesha, et al.
Publicado: (2022)

Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade
por: Wang, Minglei, et al.
Publicado: (2023)

Overcoming resistance to STING agonist therapy to incite durable protective antitumor immunity
por: Lemos, Henrique, et al.
Publicado: (2020)

Enhanced antitumor immunity by a novel small molecule HPK1 inhibitor
por: You, Dan, et al.
Publicado: (2021)

Blockades of effector T cell senescence and exhaustion synergistically enhance antitumor immunity and immunotherapy
por: Liu, Xia, et al.
Publicado: (2022)

SUN-LB056 The Pharmacological Blockade of the Splicing Factor SF3B1 Exerts Antitumor Actions in Different Endocrine-Related Cancers
por: Gahete, Manuel, et al.
Publicado: (2019)

Oral SMEDDS promotes lymphatic transport and mesenteric lymph nodes target of chlorogenic acid for effective T-cell antitumor immunity
por: Ye, Jun, et al.
Publicado: (2021)

Setdb1 is required for germline development and silencing of H3K9me3-marked endogenous retroviruses in primordial germ cells
por: Liu, Sheng, et al.
Publicado: (2014)

COVID-19 in Children: Expressions of Type I/II/III Interferons, TRIM28, SETDB1, and Endogenous Retroviruses in Mild and Severe Cases
por: Tovo, Pier-Angelo, et al.
Publicado: (2021)

SAT-147 Endogenous Expression of TCF21 by CRISPR/dCas9 System Results in Different Biological Responses in Adrenocortical Carcinoma and Hepatocarcinoma
por: Kremer, Jean Lucas, et al.
Publicado: (2020)

Combining IL-2-based immunotherapy with commensal probiotics produces enhanced antitumor immune response and tumor clearance
por: Shi, Linlin, et al.
Publicado: (2020)

Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein
por: Torres, Nicolas, et al.
Publicado: (2020)

Amino acids and RagD potentiate mTORC1 activation in CD8(+) T cells to confer antitumor immunity
por: Zhang, Yiwen, et al.
Publicado: (2021)

Epstein–Barr Virus–Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1
por: Ge, Junshang, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_85sh1t60eokom8smf67k27jki0