Reduced Proteolytic Cleavage of von Willebrand Factor Leads to Aortic Valve Stenosis and Load-Dependent Ventricular Remodeling

We hypothesized that excess endothelial-associated von Willebrand factor (vWF) and secondary platelet adhesion contribute to aortic valve stenosis (AS). We studied hyperlipidemic mice lacking ADAMTS13 (LDLR(−/−)AD13(−/−)), which cleaves endothelial-associated vWF multimers. On echocardiography and m...

Descripción completa

Detalles Bibliográficos
Autores principales: Ozawa, Koya, Muller, Matthew A., Varlamov, Oleg, Hagen, Matthew W., Packwood, William, Morgan, Terry K., Xie, Aris, López, Claudia S., Chung, Dominic, Chen, Junmei, López, José A., Lindner, Jonathan R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research - Preclinical
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357566/
https://www.ncbi.nlm.nih.gov/pubmed/35958695
http://dx.doi.org/10.1016/j.jacbts.2022.02.021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9357566/
https://www.ncbi.nlm.nih.gov/pubmed/35958695
http://dx.doi.org/10.1016/j.jacbts.2022.02.021

Ejemplares similares