Synthesis and Discovery of Ligustrazine–Heterocycle Derivatives as Antitumor Agents

Ligustrazine (TMP) is a natural pyrazine alkaloid extracted from the roots of Ligusticum Chuanxiong Hort, which has the potential as an antitumor agent. A series of 33 ligustrazine–heterocycle (TMPH) derivatives were designed, synthesized, and investigated via antitumor screening assays, molecular d...

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Detalles Bibliográficos
Autores principales: Ma, Shitang, Zhang, Ning, Hou, Jiafu, Liu, Shijuan, Wang, Jiawen, Lu, Baowei, Zhu, Fucheng, Wei, Peipei, Hong, Ge, Liu, Tianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358002/
https://www.ncbi.nlm.nih.gov/pubmed/35958230
http://dx.doi.org/10.3389/fchem.2022.941367

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358002/
https://www.ncbi.nlm.nih.gov/pubmed/35958230
http://dx.doi.org/10.3389/fchem.2022.941367

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