Cargando…

Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data

BACKGROUND: The incidence of bilateral breast cancer (BBC) is low, accounting for 5% of patients with breast cancer. This study aimed to investigate the clinicopathological features and prognosis of synchronous bilateral breast cancer (SBBC) and metachronous bilateral breast cancer (MBBC) in the Chi...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Chenyan, Zheng, Yiqiong, Geng, Rui, Hu, Huayu, Zhong, Yuting, Guan, Qingyu, Zhang, Yanjun, Li, Xiru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358492/
https://www.ncbi.nlm.nih.gov/pubmed/35957718
http://dx.doi.org/10.21037/atm-21-5400
_version_ 1784763941497339904
author Hong, Chenyan
Zheng, Yiqiong
Geng, Rui
Hu, Huayu
Zhong, Yuting
Guan, Qingyu
Zhang, Yanjun
Li, Xiru
author_facet Hong, Chenyan
Zheng, Yiqiong
Geng, Rui
Hu, Huayu
Zhong, Yuting
Guan, Qingyu
Zhang, Yanjun
Li, Xiru
author_sort Hong, Chenyan
collection PubMed
description BACKGROUND: The incidence of bilateral breast cancer (BBC) is low, accounting for 5% of patients with breast cancer. This study aimed to investigate the clinicopathological features and prognosis of synchronous bilateral breast cancer (SBBC) and metachronous bilateral breast cancer (MBBC) in the Chinese population. METHODS: Patients with BBC, including SBBC and MBBC, were selected from 6,162 breast cancer patients who underwent surgery at the Chinese People’s Liberation Army (PLA) General Hospital between January 2007 and December 2019. Furthermore, patients with unilateral breast cancer (UBC) who underwent surgery at the same time were randomly selected at a ratio of 1:2 as the control group. Clinicopathological features and prognosis were compared between the groups. RESULTS: In all, 123 (2.0%) patients with BBC were enrolled in this study, including 98 (1.6%) SBBC and 25 (0.4%) MBBC patients. A total of 280 patients with UBC were selected for the control group. Compared with patients with UBC, patients with SBBC were more likely to be older and have a family history of breast cancer, non-infiltrative carcinoma, lower pathological tumor-node-metastasis (pTNM) stage, and luminal A type breast cancer as their first tumor. Patients with MBBC were more likely to be postmenopausal and have hormone receptor [estrogen receptor (ER)/progesterone receptor (PR)] negativity, a higher pTNM stage, and a triple-negative first tumor. Patients with UBC with ER/PR (−) were more likely to develop contralateral breast cancer (CBC) than those with ER/PR (+). There was no significant difference in overall survival (OS) and disease-free survival (DFS) between patients with SBBC and patients with UBC. Patients with MBBC had worse DFS than those with UBC, but OS was similar for both types of patients. Patients with MBBC <55 years at first diagnosis had significantly shorter DFS compared to those with SBBC and UBC. A multivariate Cox proportional hazards model revealed that age ≥55 years and ER/PR negativity of the first tumor were independent risk factors for OS. Independent risk factors for DFS included MBBC, age <55 years, family history of other malignant tumors, ER/PR (−), lymphovascular invasion, and N stage ≥2 of the first tumor. CONCLUSIONS: The OS and DFS of patients with SBBC and UBC were similar. The MBBC patients, especially those <55 years old at first diagnosis, had shorter DFS than patients with UBC.
format Online
Article
Text
id pubmed-9358492
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-93584922022-08-10 Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data Hong, Chenyan Zheng, Yiqiong Geng, Rui Hu, Huayu Zhong, Yuting Guan, Qingyu Zhang, Yanjun Li, Xiru Ann Transl Med Original Article BACKGROUND: The incidence of bilateral breast cancer (BBC) is low, accounting for 5% of patients with breast cancer. This study aimed to investigate the clinicopathological features and prognosis of synchronous bilateral breast cancer (SBBC) and metachronous bilateral breast cancer (MBBC) in the Chinese population. METHODS: Patients with BBC, including SBBC and MBBC, were selected from 6,162 breast cancer patients who underwent surgery at the Chinese People’s Liberation Army (PLA) General Hospital between January 2007 and December 2019. Furthermore, patients with unilateral breast cancer (UBC) who underwent surgery at the same time were randomly selected at a ratio of 1:2 as the control group. Clinicopathological features and prognosis were compared between the groups. RESULTS: In all, 123 (2.0%) patients with BBC were enrolled in this study, including 98 (1.6%) SBBC and 25 (0.4%) MBBC patients. A total of 280 patients with UBC were selected for the control group. Compared with patients with UBC, patients with SBBC were more likely to be older and have a family history of breast cancer, non-infiltrative carcinoma, lower pathological tumor-node-metastasis (pTNM) stage, and luminal A type breast cancer as their first tumor. Patients with MBBC were more likely to be postmenopausal and have hormone receptor [estrogen receptor (ER)/progesterone receptor (PR)] negativity, a higher pTNM stage, and a triple-negative first tumor. Patients with UBC with ER/PR (−) were more likely to develop contralateral breast cancer (CBC) than those with ER/PR (+). There was no significant difference in overall survival (OS) and disease-free survival (DFS) between patients with SBBC and patients with UBC. Patients with MBBC had worse DFS than those with UBC, but OS was similar for both types of patients. Patients with MBBC <55 years at first diagnosis had significantly shorter DFS compared to those with SBBC and UBC. A multivariate Cox proportional hazards model revealed that age ≥55 years and ER/PR negativity of the first tumor were independent risk factors for OS. Independent risk factors for DFS included MBBC, age <55 years, family history of other malignant tumors, ER/PR (−), lymphovascular invasion, and N stage ≥2 of the first tumor. CONCLUSIONS: The OS and DFS of patients with SBBC and UBC were similar. The MBBC patients, especially those <55 years old at first diagnosis, had shorter DFS than patients with UBC. AME Publishing Company 2022-07 /pmc/articles/PMC9358492/ /pubmed/35957718 http://dx.doi.org/10.21037/atm-21-5400 Text en 2022 Annals of Translational Medicine. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Hong, Chenyan
Zheng, Yiqiong
Geng, Rui
Hu, Huayu
Zhong, Yuting
Guan, Qingyu
Zhang, Yanjun
Li, Xiru
Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data
title Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data
title_full Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data
title_fullStr Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data
title_full_unstemmed Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data
title_short Clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on Chinese data
title_sort clinicopathological features and prognosis of bilateral breast cancer: a single-center cohort study based on chinese data
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358492/
https://www.ncbi.nlm.nih.gov/pubmed/35957718
http://dx.doi.org/10.21037/atm-21-5400
work_keys_str_mv AT hongchenyan clinicopathologicalfeaturesandprognosisofbilateralbreastcancerasinglecentercohortstudybasedonchinesedata
AT zhengyiqiong clinicopathologicalfeaturesandprognosisofbilateralbreastcancerasinglecentercohortstudybasedonchinesedata
AT gengrui clinicopathologicalfeaturesandprognosisofbilateralbreastcancerasinglecentercohortstudybasedonchinesedata
AT huhuayu clinicopathologicalfeaturesandprognosisofbilateralbreastcancerasinglecentercohortstudybasedonchinesedata
AT zhongyuting clinicopathologicalfeaturesandprognosisofbilateralbreastcancerasinglecentercohortstudybasedonchinesedata
AT guanqingyu clinicopathologicalfeaturesandprognosisofbilateralbreastcancerasinglecentercohortstudybasedonchinesedata
AT zhangyanjun clinicopathologicalfeaturesandprognosisofbilateralbreastcancerasinglecentercohortstudybasedonchinesedata
AT lixiru clinicopathologicalfeaturesandprognosisofbilateralbreastcancerasinglecentercohortstudybasedonchinesedata