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Structural basis for acyl chain control over glycosphingolipid sorting and vesicular trafficking

The complex sphingolipids exhibit a diversity of ceramide acyl chain structures that influence their trafficking and intracellular distributions, but it remains unclear how the cell discerns among the different ceramides to affect such sorting. To address the mechanism, we synthesize a library of GM...

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Detalles Bibliográficos
Autores principales: Schmieder, Stefanie S., Tatituri, Raju, Anderson, Michael, Kelly, Kate, Lencer, Wayne I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358721/
https://www.ncbi.nlm.nih.gov/pubmed/35830800
http://dx.doi.org/10.1016/j.celrep.2022.111063