Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk

BACKGROUND: Osteoarthritis is highly heritable and genome-wide studies have identified single nucleotide polymorphisms (SNPs) associated with the disease. One such locus is marked by SNP rs11732213 (T > C). Genotype at rs11732213 correlates with the methylation levels of nearby CpG dinucleotides...

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Detalles Bibliográficos
Autores principales: Brumwell, Abby, Aubourg, Guillaume, Hussain, Juhel, Parker, Eleanor, Deehan, David J., Rice, Sarah J., Loughlin, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358880/
https://www.ncbi.nlm.nih.gov/pubmed/35941660
http://dx.doi.org/10.1186/s13075-022-02882-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358880/
https://www.ncbi.nlm.nih.gov/pubmed/35941660
http://dx.doi.org/10.1186/s13075-022-02882-y

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