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Identification of TMEM129, encoding a ubiquitin-protein ligase, as an effector gene of osteoarthritis genetic risk
BACKGROUND: Osteoarthritis is highly heritable and genome-wide studies have identified single nucleotide polymorphisms (SNPs) associated with the disease. One such locus is marked by SNP rs11732213 (T > C). Genotype at rs11732213 correlates with the methylation levels of nearby CpG dinucleotides...
Autores principales: | Brumwell, Abby, Aubourg, Guillaume, Hussain, Juhel, Parker, Eleanor, Deehan, David J., Rice, Sarah J., Loughlin, John |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358880/ https://www.ncbi.nlm.nih.gov/pubmed/35941660 http://dx.doi.org/10.1186/s13075-022-02882-y |
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