Stereochemical course of cobalamin-dependent radical SAM methylation by TokK and ThnK

Complex carbapenems are important clinical antibiotics for difficult-to-treat infections. An essential step in the biosyntheses of these natural products is stereospecific methylation at C6 and subsequent alkylations by cobalamin-dependent radical SAM methylases such as TokK and ThnK. We have prepar...

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Detalles Bibliográficos
Autores principales: Lichstrahl, Michael S., Townsend, Craig A., Sinner, Erica K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358933/
https://www.ncbi.nlm.nih.gov/pubmed/36042702
http://dx.doi.org/10.1039/d2cb00113f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9358933/
https://www.ncbi.nlm.nih.gov/pubmed/36042702
http://dx.doi.org/10.1039/d2cb00113f

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