Two small-molecule activators share similar effector sites in the KCNQ1 channel pore but have distinct effects on voltage sensor movements

ML277 and R-L3 are two small-molecule activators of KCNQ1, the pore-forming subunit of the slowly activating potassium channel I(Ks). KCNQ1 loss-of-function mutations prolong cardiac action potential duration and are associated with long QT syndrome, which predispose patients to lethal ventricular a...

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Detalles Bibliográficos
Autores principales: Chen, Lei, Peng, Gary, Comollo, Thomas W., Zou, Xinle, Sampson, Kevin J., Larsson, H. Peter, Kass, Robert S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359618/
https://www.ncbi.nlm.nih.gov/pubmed/35957984
http://dx.doi.org/10.3389/fphys.2022.903050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359618/
https://www.ncbi.nlm.nih.gov/pubmed/35957984
http://dx.doi.org/10.3389/fphys.2022.903050

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