Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

The transformation of normal to malignant cells is accompanied by substantial changes in gene expression programs through diverse mechanisms. Here, we examined the changes in the landscape of transcription start sites and alternative promoter (AP) usage and their impact on the translatome in TCL1-dr...

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Detalles Bibliográficos
Autores principales: Ogran, Ariel, Havkin-Solomon, Tal, Becker-Herman, Shirly, David, Keren, Shachar, Idit, Dikstein, Rivka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359700/
https://www.ncbi.nlm.nih.gov/pubmed/35939046
http://dx.doi.org/10.7554/eLife.77714

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359700/
https://www.ncbi.nlm.nih.gov/pubmed/35939046
http://dx.doi.org/10.7554/eLife.77714

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