ATR Inhibitor AZD6738 (Ceralasertib) Exerts Antitumor Activity as a Monotherapy and in Combination with Chemotherapy and the PARP Inhibitor Olaparib

AZD6738 (ceralasertib) is a potent and selective orally bioavailable inhibitor of ataxia telangiectasia and Rad3-related (ATR) kinase. ATR is activated in response to stalled DNA replication forks to promote G(2)–M cell-cycle checkpoints and fork restart. Here, we found AZD6738 modulated CHK1 phosph...

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Detalles Bibliográficos
Autores principales: Wilson, Zena, Odedra, Rajesh, Wallez, Yann, Wijnhoven, Paul W.G., Hughes, Adina M., Gerrard, Joe, Jones, Gemma N., Bargh-Dawson, Hannah, Brown, Elaine, Young, Lucy A., O'Connor, Mark J., Lau, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2022
Materias:
Translational Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359726/
https://www.ncbi.nlm.nih.gov/pubmed/35078817
http://dx.doi.org/10.1158/0008-5472.CAN-21-2997

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359726/
https://www.ncbi.nlm.nih.gov/pubmed/35078817
http://dx.doi.org/10.1158/0008-5472.CAN-21-2997

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