BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia

BACKGROUND: AML (acute myeloid leukemia) is a common hematological malignancy in children with poor treatment effects and poor prognosis. Recent studies have shown that as a novel BRD4 (bromodomain containing 4) PROTACs (proteolysis targeting chimeras) degrader, GNE-987 can slow down the growth of v...

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Detalles Bibliográficos
Autores principales: Sang, Xu, Zhang, Yongping, Fang, Fang, Gao, Li, Tao, Yanfang, Li, Xiaolu, Zhang, Zimu, Wang, Jianwei, Tian, Yuanyuan, Li, Zhiheng, Yao, Di, Wu, Yumeng, Chu, Xinran, Zhang, Kunlong, Ma, Li, Lu, Lihui, Chen, Yanling, Yu, Juanjuan, Zhuo, Ran, Wu, Shuiyan, Zhang, Zhen, Pan, Jian, Hu, Shaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359861/
https://www.ncbi.nlm.nih.gov/pubmed/35958877
http://dx.doi.org/10.1155/2022/7912484

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359861/
https://www.ncbi.nlm.nih.gov/pubmed/35958877
http://dx.doi.org/10.1155/2022/7912484

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