Cytosine base editing systems with minimized off-target effect and molecular size

Cytosine base editing enables the installation of specific point mutations without double-strand breaks in DNA and is advantageous for various applications such as gene therapy, but further reduction of off-target risk and development of efficient delivery methods are desired. Here we show structure...

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Detalles Bibliográficos
Autores principales: Li, Ang, Mitsunobu, Hitoshi, Yoshioka, Shin, Suzuki, Takahisa, Kondo, Akihiko, Nishida, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359979/
https://www.ncbi.nlm.nih.gov/pubmed/35941130
http://dx.doi.org/10.1038/s41467-022-32157-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9359979/
https://www.ncbi.nlm.nih.gov/pubmed/35941130
http://dx.doi.org/10.1038/s41467-022-32157-8

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