Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

Pancreatic β-cells are prone to endoplasmic reticulum (ER) stress due to their role in insulin secretion. They require sustainable and efficient adaptive stress responses to cope with this stress. Whether episodes of chronic stress directly compromise β-cell identity is unknown. We show here under r...

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Detalles Bibliográficos
Autores principales: Chen, Chien-Wen, Guan, Bo-Jhih, Alzahrani, Mohammed R., Gao, Zhaofeng, Gao, Long, Bracey, Syrena, Wu, Jing, Mbow, Cheikh A., Jobava, Raul, Haataja, Leena, Zalavadia, Ajay H., Schaffer, Ashleigh E., Lee, Hugo, LaFramboise, Thomas, Bederman, Ilya, Arvan, Peter, Mathews, Clayton E., Gerling, Ivan C., Kaestner, Klaus H., Tirosh, Boaz, Engin, Feyza, Hatzoglou, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360004/
https://www.ncbi.nlm.nih.gov/pubmed/35941159
http://dx.doi.org/10.1038/s41467-022-32425-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360004/
https://www.ncbi.nlm.nih.gov/pubmed/35941159
http://dx.doi.org/10.1038/s41467-022-32425-7

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