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G protein coupling and activation of the metabotropic GABA(B) heterodimer
Metabotropic γ-aminobutyric acid receptor (GABA(B)R), a class C G protein-coupled receptor (GPCR) heterodimer, plays a crucial role in the central nervous system. Cryo-electron microscopy studies revealed a drastic conformational change upon activation and a unique G protein (GP) binding mode. Howev...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360005/ https://www.ncbi.nlm.nih.gov/pubmed/35941188 http://dx.doi.org/10.1038/s41467-022-32213-3 |