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G protein coupling and activation of the metabotropic GABA(B) heterodimer

Metabotropic γ-aminobutyric acid receptor (GABA(B)R), a class C G protein-coupled receptor (GPCR) heterodimer, plays a crucial role in the central nervous system. Cryo-electron microscopy studies revealed a drastic conformational change upon activation and a unique G protein (GP) binding mode. Howev...

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Detalles Bibliográficos
Autores principales:	Yang, Moon Young, Kim, Soo-Kyung, Goddard, William A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360005/ https://www.ncbi.nlm.nih.gov/pubmed/35941188 http://dx.doi.org/10.1038/s41467-022-32213-3

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