Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts

We explored the potential activity of compound 16 (Cpd16), a novel small molecule Nrf2 activator, in hydrogen peroxide (H(2)O(2))-stimulated osteoblasts. In the primary murine/human osteoblasts and MC3T3-E1 murine osteoblastic cells, Cpd16 treatment at micro-molar concentrations caused disassociatio...

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Detalles Bibliográficos
Autores principales: Zhao, Jing-wei, Tang, Pei-jun, Zhou, Zhen-tao, Xu, Gang, Li, Quan, Li, Ke-ran, Zheng, Yue-huan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360014/
https://www.ncbi.nlm.nih.gov/pubmed/35941127
http://dx.doi.org/10.1038/s41420-022-01146-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360014/
https://www.ncbi.nlm.nih.gov/pubmed/35941127
http://dx.doi.org/10.1038/s41420-022-01146-7

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