Tenuous Transcriptional Threshold of Human Sex Determination. I. SRY and Swyer Syndrome at the Edge of Ambiguity

Male sex determination in mammals is initiated by SRY, a Y-encoded transcription factor. The protein contains a high-mobility-group (HMG) box mediating sequence-specific DNA bending. Mutations causing XY gonadal dysgenesis (Swyer syndrome) cluster in the box and ordinarily arise de novo. Rare inheri...

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Detalles Bibliográficos
Autores principales: Chen, Yen-Shan, Racca, Joseph D., Weiss, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360328/
https://www.ncbi.nlm.nih.gov/pubmed/35957822
http://dx.doi.org/10.3389/fendo.2022.945030

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360328/
https://www.ncbi.nlm.nih.gov/pubmed/35957822
http://dx.doi.org/10.3389/fendo.2022.945030

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