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Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer
Cancer cachexia is a common, debilitating condition with limited therapeutic options. Using an established mouse model of lung cancer, we find that cachexia is characterized by reduced food intake, spontaneous activity, and energy expenditure accompanied by muscle metabolic dysfunction and atrophy....
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360437/ https://www.ncbi.nlm.nih.gov/pubmed/35941104 http://dx.doi.org/10.1038/s41467-022-32135-0 |