Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer

Cancer cachexia is a common, debilitating condition with limited therapeutic options. Using an established mouse model of lung cancer, we find that cachexia is characterized by reduced food intake, spontaneous activity, and energy expenditure accompanied by muscle metabolic dysfunction and atrophy....

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Detalles Bibliográficos
Autores principales: Queiroz, Andre Lima, Dantas, Ezequiel, Ramsamooj, Shakti, Murthy, Anirudh, Ahmed, Mujmmail, Zunica, Elizabeth R. M., Liang, Roger J., Murphy, Jessica, Holman, Corey D., Bare, Curtis J., Ghahramani, Gregory, Wu, Zhidan, Cohen, David E., Kirwan, John P., Cantley, Lewis C., Axelrod, Christopher L., Goncalves, Marcus D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360437/
https://www.ncbi.nlm.nih.gov/pubmed/35941104
http://dx.doi.org/10.1038/s41467-022-32135-0

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