Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity

Argonaute proteins are programmable nucleases that have defense and regulatory functions in both eukaryotes and prokaryotes. All known prokaryotic Argonautes (pAgos) characterized so far act on DNA targets. Here, we describe a new class of pAgos that uniquely use DNA guides to process RNA targets. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Lisitskaya, Lidiya, Shin, Yeonoh, Agapov, Aleksei, Olina, Anna, Kropocheva, Ekaterina, Ryazansky, Sergei, Aravin, Alexei A., Esyunina, Daria, Murakami, Katsuhiko S., Kulbachinskiy, Andrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360449/
https://www.ncbi.nlm.nih.gov/pubmed/35941106
http://dx.doi.org/10.1038/s41467-022-32079-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360449/
https://www.ncbi.nlm.nih.gov/pubmed/35941106
http://dx.doi.org/10.1038/s41467-022-32079-5

Ejemplares similares