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Programmable RNA targeting by bacterial Argonaute nucleases with unconventional guide binding and cleavage specificity
Argonaute proteins are programmable nucleases that have defense and regulatory functions in both eukaryotes and prokaryotes. All known prokaryotic Argonautes (pAgos) characterized so far act on DNA targets. Here, we describe a new class of pAgos that uniquely use DNA guides to process RNA targets. T...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9360449/ https://www.ncbi.nlm.nih.gov/pubmed/35941106 http://dx.doi.org/10.1038/s41467-022-32079-5 |