Cargando…
Therapeutic validation of an orphan G protein‐coupled receptor: The case of GPR84
Despite the importance of members of the GPCR superfamily as targets of a broad range of effective medicines many GPCRs remain poorly characterised. GPR84 is an example. Expression of GPR84 is strongly up regulated in immune cells in a range of pro‐inflammatory settings and clinical trials to treat...
Autores principales: | Marsango, Sara, Barki, Natasja, Jenkins, Laura, Tobin, Andrew B., Milligan, Graeme |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361006/ https://www.ncbi.nlm.nih.gov/pubmed/32869860 http://dx.doi.org/10.1111/bph.15248 |
Ejemplares similares
-
Discovery and Characterization of Novel Antagonists
of the Proinflammatory Orphan Receptor GPR84
por: Jenkins, Laura, et al.
Publicado: (2021) -
Investigating
the Structure–Activity Relationship
of 1,2,4-Triazine G-Protein-Coupled Receptor 84 (GPR84) Antagonists
por: Mahindra, Amit, et al.
Publicado: (2022) -
Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84
por: Mahmud, Zobaer Al, et al.
Publicado: (2017) -
Therapeutic Opportunities and Challenges in Targeting
the Orphan G Protein-Coupled Receptor GPR35
por: Quon, Tezz, et al.
Publicado: (2020) -
Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands
por: Marsango, Sara, et al.
Publicado: (2022)