Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening

The mechanisms linking systemic infection to hyperinflammation and immune dysfunction in sepsis are poorly understood. Extracellular histones promote sepsis pathology, but their source and mechanism of action remain unclear. Here, we show that by controlling fungi and bacteria captured by splenic ma...

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Detalles Bibliográficos
Autores principales: Ioannou, Marianna, Hoving, Dennis, Aramburu, Iker Valle, Temkin, Mia I., De Vasconcelos, Nathalia M., Tsourouktsoglou, Theodora-Dorita, Wang, Qian, Boeing, Stefan, Goldstone, Robert, Vernardis, Spyros, Demichev, Vadim, Ralser, Markus, David, Sascha, Stahl, Klaus, Bode, Christian, Papayannopoulos, Venizelos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361272/
https://www.ncbi.nlm.nih.gov/pubmed/35945238
http://dx.doi.org/10.1038/s41467-022-32320-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361272/
https://www.ncbi.nlm.nih.gov/pubmed/35945238
http://dx.doi.org/10.1038/s41467-022-32320-1

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