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Microbe capture by splenic macrophages triggers sepsis via T cell-death-dependent neutrophil lifespan shortening
The mechanisms linking systemic infection to hyperinflammation and immune dysfunction in sepsis are poorly understood. Extracellular histones promote sepsis pathology, but their source and mechanism of action remain unclear. Here, we show that by controlling fungi and bacteria captured by splenic ma...
Autores principales: | Ioannou, Marianna, Hoving, Dennis, Aramburu, Iker Valle, Temkin, Mia I., De Vasconcelos, Nathalia M., Tsourouktsoglou, Theodora-Dorita, Wang, Qian, Boeing, Stefan, Goldstone, Robert, Vernardis, Spyros, Demichev, Vadim, Ralser, Markus, David, Sascha, Stahl, Klaus, Bode, Christian, Papayannopoulos, Venizelos |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361272/ https://www.ncbi.nlm.nih.gov/pubmed/35945238 http://dx.doi.org/10.1038/s41467-022-32320-1 |
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