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Hypoxia-Induced Sarcoplasmic Reticulum Ca(2+) Leak Is Reversed by Ryanodine Receptor Stabilizer JTV-519 in HL-1 Cardiomyocytes

BACKGROUND: To assess whether hypoxia, as can be found in obstructive sleep apnea syndrome, is causally associated with the development of heart failure through a direct effect on calcium leakage from the sarcoplasmic reticulum. METHODS: The impact of hypoxia on sarcoplasmic reticulum calcium leakag...

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Detalles Bibliográficos
Autores principales: Duc Trinh, Minh, Fiserova, Ivana, Vacek, Lukas, Heide, Marek, Pala, Jan, Tousek, Petr, Polak, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Turkish Society of Cardiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9361329/
https://www.ncbi.nlm.nih.gov/pubmed/35703484
http://dx.doi.org/10.5152/AnatolJCardiol.2022.1223