A feedback loop between platelets and NETs amplifies inflammation in severe sepsis

Sepsis-derived S100A8/A9 induces GSDMD-dependent platelet pyroptosis via the TLR4–ROS–NLRP3–caspase 1 pathway, leading to the release of oxidized mitochondrial DNA that contributes to the formation of neutrophil extracellular traps (NETs). NETs in turn release S100A8/A9 and accelerate platelet pyrop...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362555/
https://www.ncbi.nlm.nih.gov/pubmed/35967458
http://dx.doi.org/10.1038/s44161-022-00110-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362555/
https://www.ncbi.nlm.nih.gov/pubmed/35967458
http://dx.doi.org/10.1038/s44161-022-00110-z

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