A feedback loop between platelets and NETs amplifies inflammation in severe sepsis

Sepsis-derived S100A8/A9 induces GSDMD-dependent platelet pyroptosis via the TLR4–ROS–NLRP3–caspase 1 pathway, leading to the release of oxidized mitochondrial DNA that contributes to the formation of neutrophil extracellular traps (NETs). NETs in turn release S100A8/A9 and accelerate platelet pyrop...

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Detalles Bibliográficos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Research Briefing
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362555/
https://www.ncbi.nlm.nih.gov/pubmed/35967458
http://dx.doi.org/10.1038/s44161-022-00110-z
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collection PubMed
description Sepsis-derived S100A8/A9 induces GSDMD-dependent platelet pyroptosis via the TLR4–ROS–NLRP3–caspase 1 pathway, leading to the release of oxidized mitochondrial DNA that contributes to the formation of neutrophil extracellular traps (NETs). NETs in turn release S100A8/A9 and accelerate platelet pyroptosis, forming a positive feedback loop and thereby amplifying the production of proinflammatory cytokines.
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spelling pubmed-93625552022-08-10 A feedback loop between platelets and NETs amplifies inflammation in severe sepsis Nat Cardiovasc Res Research Briefing Sepsis-derived S100A8/A9 induces GSDMD-dependent platelet pyroptosis via the TLR4–ROS–NLRP3–caspase 1 pathway, leading to the release of oxidized mitochondrial DNA that contributes to the formation of neutrophil extracellular traps (NETs). NETs in turn release S100A8/A9 and accelerate platelet pyroptosis, forming a positive feedback loop and thereby amplifying the production of proinflammatory cytokines. Nature Publishing Group UK 2022-08-08 2022 /pmc/articles/PMC9362555/ /pubmed/35967458 http://dx.doi.org/10.1038/s44161-022-00110-z Text en © Springer Nature Limited 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Research Briefing
A feedback loop between platelets and NETs amplifies inflammation in severe sepsis
title A feedback loop between platelets and NETs amplifies inflammation in severe sepsis
title_full A feedback loop between platelets and NETs amplifies inflammation in severe sepsis
title_fullStr A feedback loop between platelets and NETs amplifies inflammation in severe sepsis
title_full_unstemmed A feedback loop between platelets and NETs amplifies inflammation in severe sepsis
title_short A feedback loop between platelets and NETs amplifies inflammation in severe sepsis
title_sort feedback loop between platelets and nets amplifies inflammation in severe sepsis
topic Research Briefing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362555/
https://www.ncbi.nlm.nih.gov/pubmed/35967458
http://dx.doi.org/10.1038/s44161-022-00110-z

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