Expression of phenylalanine ammonia lyase as an intracellularly free and extracellularly cell surface-immobilized enzyme on a gut microbe as a live biotherapeutic for phenylketonuria

Phenylketonuria (PKU), a disease resulting in the disability to degrade phenylalanine (Phe) is an inborn error with a 1 in 10,000 morbidity rate on average around the world which leads to neurotoxicity. As an potential alternative to a protein-restricted diet, oral intake of engineered probiotics de...

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Detalles Bibliográficos
Autores principales: Jiang, Yu, Sun, Bingbing, Qian, Fenghui, Dong, Feng, Xu, Chongmao, Zhong, Wuling, Huang, Rui, Zhai, Qiwei, Yang, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Science China Press 2022
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362719/
https://www.ncbi.nlm.nih.gov/pubmed/35907113
http://dx.doi.org/10.1007/s11427-021-2137-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362719/
https://www.ncbi.nlm.nih.gov/pubmed/35907113
http://dx.doi.org/10.1007/s11427-021-2137-3

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