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Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation
Oxidative stress, which can cause DNA damage, can both activate TNF-R1 directly in the absence of TNF stimulation and phosphorylate c-Abl, thus promoting its cytoplasmic translocation. Persistent cytoplasmic localization of c-Abl has been associated with cellular transformation. c-Abl phosphorylates...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9362849/ https://www.ncbi.nlm.nih.gov/pubmed/35958947 http://dx.doi.org/10.2147/CMAR.S373557 |