Unveiling the “Template-Dependent” Inhibition on the Viral Transcription of SARS-CoV-2

[Image: see text] Remdesivir is one nucleotide analogue prodrug capable to terminate RNA synthesis in SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) by two distinct mechanisms. Although the “delayed chain termination” mechanism has been extensively investigated, the “template-dependent” inhibitory m...

Descripción completa

Detalles Bibliográficos
Autores principales: Luo, Xueying, Wang, Xiaowei, Yao, Yuan, Gao, Xin, Zhang, Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363016/
https://www.ncbi.nlm.nih.gov/pubmed/35912566
http://dx.doi.org/10.1021/acs.jpclett.2c01314

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363016/
https://www.ncbi.nlm.nih.gov/pubmed/35912566
http://dx.doi.org/10.1021/acs.jpclett.2c01314

Ejemplares similares