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Unveiling the “Template-Dependent” Inhibition on the Viral Transcription of SARS-CoV-2

[Image: see text] Remdesivir is one nucleotide analogue prodrug capable to terminate RNA synthesis in SARS-CoV-2 RNA-dependent RNA polymerase (RdRp) by two distinct mechanisms. Although the “delayed chain termination” mechanism has been extensively investigated, the “template-dependent” inhibitory m...

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Detalles Bibliográficos
Autores principales:	Luo, Xueying, Wang, Xiaowei, Yao, Yuan, Gao, Xin, Zhang, Lu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2022
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9363016/ https://www.ncbi.nlm.nih.gov/pubmed/35912566 http://dx.doi.org/10.1021/acs.jpclett.2c01314

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